Simvastatin Modulates the Alzheimer's Disease-Related Gene seladin-1

  1. Ramos, Maria C. 1
  2. Sierra, Saleta 1
  3. Ramirez, Carlos 1
  4. Velasco, Javier 1
  5. Burgos, Javier S. 1
  1. 1 Neuron BIO, BioPharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
Revista:
Journal of Alzheimer's Disease

ISSN: 1875-8908,  1387-2877

Año de publicación: 2012

Volumen: 28

Número: 2

Páginas: 297-301

Tipo: Artículo

DOI: 10.3233/JAD-2011-111118 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Journal of Alzheimer's Disease

Resumen

Abstract: This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.