Simvastatin Modulates the Alzheimer's Disease-Related Gene seladin-1
- Ramos, Maria C. 1
- Sierra, Saleta 1
- Ramirez, Carlos 1
- Velasco, Javier 1
- Burgos, Javier S. 1
- 1 Neuron BIO, BioPharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
ISSN: 1875-8908, 1387-2877
Argitalpen urtea: 2012
Alea: 28
Zenbakia: 2
Orrialdeak: 297-301
Mota: Artikulua
Beste argitalpen batzuk: Journal of Alzheimer's Disease
Laburpena
Abstract: This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.