Simvastatin Modulates the Alzheimer's Disease-Related Gene seladin-1
- Ramos, Maria C. 1
- Sierra, Saleta 1
- Ramirez, Carlos 1
- Velasco, Javier 1
- Burgos, Javier S. 1
- 1 Neuron BIO, BioPharma Division, Parque Tecnológico de Ciencias de la Salud, Edificio BIC, Armilla, Granada, Spain
ISSN: 1875-8908, 1387-2877
Année de publication: 2012
Volumen: 28
Número: 2
Pages: 297-301
Type: Article
D'autres publications dans: Journal of Alzheimer's Disease
Résumé
Abstract: This work describes a novel mechanism of neuroprotection by simvastatin: the modulation of seladin-1, an enzyme involved in Alzheimer's disease. Genomic and proteomic studies in human neuronal cells showed seladin-1 production to be increased in a dose- and time-dependent manner by simvastatin. This was confirmed in mice by immunohistochemical and qRT-PCR studies.