Evidence of 1,25-dihydroxyvitamin D synthesis by the rat Walker carcinosarcoma 256
- Traba, M.L. 1
- Risco, F. 1
- Hurtado, J. 1
- F. de Miguel 1
- Esbrit, P. 1
- Rapado, A. 1
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1
Fundación Jiménez Díaz
info
ISSN: 0304-3835
Datum der Publikation: 1990
Ausgabe: 53
Nummer: 1
Seiten: 5-8
Art: Artikel
Andere Publikationen in: Cancer Letters
Zusammenfassung
We tested the existence of 25-hydroxyvitamin D-1α-hydroxylase activity in the Walker carcinosarcoma 256 implanted in rats. This tumour has been shown to induce hypercalcaemia in the host animal. We found this enzyme activity in tumour homogenates, which was in the same range as that in the kidney of tumour-bearing rats. Our results suggest that 1,25-dihydroxyvitamin D synthesised by the Walker tumour might be involved in the mechanism responsible for the hypercalcaemia in the host rat.
Bibliographische Referenzen
- Abe, (1981), 78, pp. 4990
- Bradford, (1976), Anal. Biochem., 72, pp. 248, 10.1016/0003-2697(76)90527-3
- Breslau, (1984), Ann. Intern. Med., 100, pp. 1, 10.7326/0003-4819-100-1-1
- De Miguel, (1989), J. Bone Min. Res., 4, pp. S320
- Eisman, (1984), pp. 365
- Horiuchi, (1987), Science, 238, pp. 1566, 10.1126/science.3685994
- MacIntyre, (1981), Biochem. Biophys. Res. Commun., 101, pp. 1131, 10.1016/0006-291X(81)91565-5
- Godsall, (1986), Recent. Prog. Hormone Res., 42, pp. 705
- Hurtado, (1988), Med. Sci. Res., 16, pp. 571
- Insogna, (1984), Endocrinology, 114, pp. 888, 10.1210/endo-114-3-888
- Koga, (1988), Cancer Res., 48, pp. 2734
- Lobaugh, (1986), Methods Enzymol., 123, pp. 159, 10.1016/S0076-6879(86)23019-0
- Mangelsdorf, (1984), J. Cell. Biol., 98, pp. 391, 10.1083/jcb.98.2.391
- Minne, (1978), Acta Endocrinol., 78, pp. 613, 10.1530/acta.0.0780613
- Mudde, (1987), Cancer, 59, pp. 1543, 10.1002/1097-0142(19870501)59:9<1543::AID-CNCR2820590902>3.0.CO;2-L
- Mundy, (1988), J. Clin. Invest., 82, pp. 1, 10.1172/JCI113555
- Reichel, (1989), New Engl. J. Med., 320, pp. 980, 10.1056/NEJM198904133201506
- Risco, (1987), Clin. Chem., 33, pp. 720, 10.1093/clinchem/33.5.720a
- Rodan, (1983), J. Clin. Invest., 72, pp. 1511, 10.1172/JCI111108
- Rosenthal, (1985), J. Clin. Endocrinol. Metab., 60, pp. 29, 10.1210/jcem-60-1-29
- Scharla, (1989), Bone Min., 6, pp. 155, 10.1016/0169-6009(89)90047-0
- Scharla, (1987), Acta Endocrinol., 114, pp. 50, 10.1530/acta.0.114S050-a
- Schmidt-Gayk, (1979), Eur. J. Cancer, 15, pp. 1211, 10.1016/0014-2964(79)90246-9
- Traba, (1982), pp. 805
- Traba, (1989), Med. Sci. Res., 17, pp. 81
- Yamamoto, (1987), J. Clin. Endocrinol. Metab., 64, pp. 175, 10.1210/jcem-64-1-175
- Yamaoka, (1986), Biochem. Biophys. Res. Commun., 139, pp. 1292, 10.1016/S0006-291X(86)80318-7