Evidence of 1,25-dihydroxyvitamin D synthesis by the rat Walker carcinosarcoma 256

  1. Traba, M.L. 1
  2. Risco, F. 1
  3. Hurtado, J. 1
  4. F. de Miguel 1
  5. Esbrit, P. 1
  6. Rapado, A. 1
  1. 1 Fundación Jiménez Díaz
    info

    Fundación Jiménez Díaz

    Madrid, España

    ROR https://ror.org/049nvyb15

Revista:
Cancer Letters

ISSN: 0304-3835

Any de publicació: 1990

Volum: 53

Número: 1

Pàgines: 5-8

Tipus: Article

DOI: 10.1016/0304-3835(90)90003-G GOOGLE SCHOLAR

Altres publicacions en: Cancer Letters

Resum

We tested the existence of 25-hydroxyvitamin D-1α-hydroxylase activity in the Walker carcinosarcoma 256 implanted in rats. This tumour has been shown to induce hypercalcaemia in the host animal. We found this enzyme activity in tumour homogenates, which was in the same range as that in the kidney of tumour-bearing rats. Our results suggest that 1,25-dihydroxyvitamin D synthesised by the Walker tumour might be involved in the mechanism responsible for the hypercalcaemia in the host rat.

Referències bibliogràfiques

  • Abe, (1981), 78, pp. 4990
  • Bradford, (1976), Anal. Biochem., 72, pp. 248, 10.1016/0003-2697(76)90527-3
  • Breslau, (1984), Ann. Intern. Med., 100, pp. 1, 10.7326/0003-4819-100-1-1
  • De Miguel, (1989), J. Bone Min. Res., 4, pp. S320
  • Eisman, (1984), pp. 365
  • Horiuchi, (1987), Science, 238, pp. 1566, 10.1126/science.3685994
  • MacIntyre, (1981), Biochem. Biophys. Res. Commun., 101, pp. 1131, 10.1016/0006-291X(81)91565-5
  • Godsall, (1986), Recent. Prog. Hormone Res., 42, pp. 705
  • Hurtado, (1988), Med. Sci. Res., 16, pp. 571
  • Insogna, (1984), Endocrinology, 114, pp. 888, 10.1210/endo-114-3-888
  • Koga, (1988), Cancer Res., 48, pp. 2734
  • Lobaugh, (1986), Methods Enzymol., 123, pp. 159, 10.1016/S0076-6879(86)23019-0
  • Mangelsdorf, (1984), J. Cell. Biol., 98, pp. 391, 10.1083/jcb.98.2.391
  • Minne, (1978), Acta Endocrinol., 78, pp. 613, 10.1530/acta.0.0780613
  • Mudde, (1987), Cancer, 59, pp. 1543, 10.1002/1097-0142(19870501)59:9<1543::AID-CNCR2820590902>3.0.CO;2-L
  • Mundy, (1988), J. Clin. Invest., 82, pp. 1, 10.1172/JCI113555
  • Reichel, (1989), New Engl. J. Med., 320, pp. 980, 10.1056/NEJM198904133201506
  • Risco, (1987), Clin. Chem., 33, pp. 720, 10.1093/clinchem/33.5.720a
  • Rodan, (1983), J. Clin. Invest., 72, pp. 1511, 10.1172/JCI111108
  • Rosenthal, (1985), J. Clin. Endocrinol. Metab., 60, pp. 29, 10.1210/jcem-60-1-29
  • Scharla, (1989), Bone Min., 6, pp. 155, 10.1016/0169-6009(89)90047-0
  • Scharla, (1987), Acta Endocrinol., 114, pp. 50, 10.1530/acta.0.114S050-a
  • Schmidt-Gayk, (1979), Eur. J. Cancer, 15, pp. 1211, 10.1016/0014-2964(79)90246-9
  • Traba, (1982), pp. 805
  • Traba, (1989), Med. Sci. Res., 17, pp. 81
  • Yamamoto, (1987), J. Clin. Endocrinol. Metab., 64, pp. 175, 10.1210/jcem-64-1-175
  • Yamaoka, (1986), Biochem. Biophys. Res. Commun., 139, pp. 1292, 10.1016/S0006-291X(86)80318-7