Estudio piloto sobre el diagnóstico y factores relacionados con la hiposialia en pacientes con xerostomía en una clínica universitaria.
- Medina López-Chicheri P 1
- Muñoz Corcuera M 1
- Navarrete Marabini N 1
- Gil-Abando Lozano G . 1
-
1
Universidad Europea de Madrid
info
Year of publication: 2021
Volume: 18
Pages: 193-199
Type: Article
Abstract
Xerostomia is a subjective sensation of dry mouth that may or may not be accompanied by a decrease in the amount of saliva. Hyposialia is the reduction in salivary ow measured by a sialometry. The aim of the study was to dene the total percentage of patients with true hyposialia in a group of patients with xerostomia and to analyze the differences between patients with xerostomia associated with hyposalia and patients with subjective xerostomia.28 patients who referred xerostomia were part of the study between November and March 2020-2021 at the Polyclinic of the European University of Madrid. A comprehensive medical history was fullled, three questionnaires were completed: Xerostomia Inventory, Perceived Stress Scale, and OHIP-14, and unstimulated sialometry was performed for ve minutes. Data analysis was performed with the Stata IC v. 14.82% of the total patients who reported dry mouth were women with a mean age of 59.14 years. Less than half of the patients (46%) had hyposialia as evidenced by sialometry. There were more patients with dental prostheses in the group suffering from hyposialia compared to the group with normal salivary ow. Both groups showed a similar number of xerostomizing diseases and drugs. Regarding the completed questionnaires, there was no signicant difference in the results of both groups.
Bibliographic References
- Navazesh M, Christensen CM, Brightman VJ. Clinical criteria for the diagnosis of salivary gland hypofunction. J Dent Res 1992; 71: 1363–9.
- 2. Hopcraft MS, Tan C. Xerostomia: an update for clinicians. Aust Dent J 2010;55(3):238-44.
- 3. Thomson WM, Chalmers JM, Spencer AJ, Ketabi M. The occurrence of xerostomia and salivary gland hypofunction in a population-based sample of older South Australians. Spec Care Dent 1999;19:20–3.
- 4. Dodds MW, Johnson DA, Yeh CK. Health benets of saliva: a review. J Dent 2005;33(3):223–33.
- 5. Wolff A, Joshi RK, Ekström J, y cols. A guide to medications inducing salivary gland dysfunction, xerostomia, and subjective sialorrhea: A systematic review sponsored by the World Workshop on Oral Medicine VI. Drugs R D 2017;17(1):1-28.
- 6. Vasconcelos AC, Soares MS, Almeida PC, Soares TC. Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients. J Oral Sci 2010;52(2):293-8.
- 7. Anttila SS, Knuuttila ML, Sakki TK. Depressive symptoms as an underlying factor of the sensation of dry mouth. Psychosom Med 1998;60:215-8
- 8. Cersósimo MG, Tumilasci OR, Raina GB, y cols. Hyposialorrhea as an early manifestation of Parkinson disease. Auton Neurosci 2009;150:150–1.
- 9. Mercadante V, Al Hamad A, Lodi G, Porter S, Fedele S. Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis. Oral Oncol 2017;66:64-74.
- 10. Ferlay J, Soerjomataram I, Dikshit R, y cols. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015 1;136:E359-86.
- 11. Bergdahl M, Bergdahl J. Low unstimulated salivary ow and subjective oral dryness: association with medication, anxiety, depression, and stress. J Dent Res 2000;79:1652-8.
- 12. Petrušić N, Posavac M, Sabol I, Mravak-Stipetić M. The effect of tobacco smoking on salivation. Acta Stomatol Croat 2015;49:309-15.
- 13. Thomson WM, Chalmers JM, Spencer AJ, Williams SM. The Xerostomia Inventory: a multi-item approach to measuring dry mouth. Community Dent Health 1999; 16: 12– 17.
- 14. Osailan SM, Pramanik R, Shirlaw P, Proctor GB, Challacombe SJ. Clinical assessment of oral dryness: development of a scoring system related to salivary ow and mucosal wetness. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:597-603.
- 15. Navazesh M, Kumar SK. Measuring salivary ow: challenges and opportunities. J Am Dent Assoc 2008; 139 Suppl: 35S– 40S.
- 16. Navazesh M, Christensen CM, Brightman VJ. Clinical criteria for the diagnosis of salivary gland hypofunction. J Dent Res 1992; 71: 1363– 9.
- 17. Ship J, Fox PC, Baum BJ. How much saliva is enough? ‘Normal’ function dened. J Am Dent Assoc 1991; 122: 63– 9.
- 18. Visvanathan V, Nix P. Managing the patient presenting with xerostomia: a review. Int J Clin Pract 2010; 64:404-7.
- 19. Gómez-Moreno G, Cabrera-Ayala M, Aguilar-Salvatierra A, y cols. Evaluation of the efcacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial. Gerodontology 2014; 31:274-80.
- 20. LeVeque FG, Montgomery M, Potter D, y cols., A multicenter, randomized, double-blind, placebo-controlled, dose-titration study of oral pilocarpine for treatment of radiation-induced xerostomia in head and neck cancer patients. J Clin Oncol 1993;11:1124-31.
- 21. Nederfors MW, Isaksson R, Mornstad H, Dahlof C. Prevalence of perceived symptoms of dry mouth in an adult Swedish population- relation to age, sex and pharmacotherapy. Commun Dent Oral Epidemiol 1997; 25:211-6.
- 22. Välimaa H, Savolainen S, Soukka T, y cols. Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands. J Endocrinol 2004;180:55-62.
- 23. Minicucci EM, Pires RB, Vieira RA, Miot HA, Sposto MR. Assessing the impact of menopause on salivary ow and xerostomia. Aust Dent J 2013;58:230-4.
- 24. Eliasson L, Carlén A, Laine M, Birkhed D. Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol). Arch Oral Biol 2003;48:511-7.
- 25. Yeh C-K, Johnson DA, Dodds MWJ. Impact of aging on human salivary gland function: a community-based study. Aging: Clinical and Experimental Research 1998;10:421–8.
- 26. Tanaka A, Kellesarian SV, Arany S. Xerostomia and patients’ satisfaction with removable denture performance: systematic review. Quintessence Int 2021;52:46-55.
- 27. Gabay EL. Flow rate, sodium and potassium concentration in mixed saliva of complete denture-wearers. J Oral Rehabil 1980;7:435-43.
- 28. Wolff A, Ofer S, Raviv M, Helft M, Cardash HS. The ow rate of whole and submandibular/sublingual gland saliva in patients receiving replacement complete dentures. J Oral Rehabil 2004;31:340-3.
- 29. Bulthuis MS, Jan Jager DH, Brand HS. Relationship among perceived stress, xerostomia, and salivary ow rate in patients visiting a saliva clinic. Clin Oral Investig 2018;22:3121-3127.
- 30. Van der Putten GJ, Brand HS, Schols JM, de Baat C. The diagnostic suitability of a xerostomia questionnaire and the association between xerostomia, hyposalivation and medication use in a group of nursing home residents. Clin Oral Investig 2011;15:185-92.
- 31. Villa A, Wolff A, Narayana N, y cols. World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction. Oral Dis 2016;22:365-82.
- 32. Dawes C. Circadian rhythms in human salivary ow rate and composition. J Physiol 1972;220(3):529-45.
- 33. Papagerakis S, Zheng L, Schnell S, y cols. The circadian clock in oral health and diseases. J Dent Res 2014;93(1):27-35