Vascular proteomics

Referencias bibliográficas

• [1] Gállego-Delgado, J., Lázaro, A., Osende, J., Barderas, M. G.etal., Proteomic approach in the search of new cardiovascularbiomarkers.Kid. Int.2005,68, S1–S5.
• [2] Ross, R., Atherosclerosis, an inflammatory disease.N. Engl.J. Med.1999,340, 115–126.
• [3] Libby, P., Ridkker, P. M., Maseri, A., Inflammation and athero-sclerosis.Circulation2002,105, 1135–1143
• [4] Moreno, P. R., Falk, E., Palacios, I. F., Nevell, J. B.et al., Mac-rophage infiltration in acute coronary syndromes. Implica-tions for plaque rupture.Circulation1994,90, 775–778.
• [5] Ruggeri, Z. M., Platelets in atherothrombosis.Nat. Med.2002,8, 1227–1234.
• [6] Fuster, V., Badimon, L., Badimon, J. J., Chesebro, J. H., Thepathogenesis of coronary artery disease and the acute cor-onary syndromes (1).N. Engl. J. Med.1992,326, 242–250.
• [7] Claessens, C., Claessens, P., Claessens, M., Verschueren, R.,Claessens, J., Changes in mortality of acute myocardialinfarction as a function of a changing tratment during thelast two decades.Jpn. Heart.2000,41, 683–695.
• [8] Mosterd, A., Cost, B., Hoes, A. W., De Bruijne, M. C.et al.,The prognosis of heart failure in general population: TheRotterdam study.Eur. Heart. J.2001,22, 1318–1327.
• [9] Van de Werf, F., Ardissino, D., Betriu, A., Cokkinos, D. V.et al.,Task Force Report Management of acute myocardial infarc-tion in patients presenting with ST-segment elevation.Eur.Heart J.2003,24, 28–66.
• [10] Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S.et al.,C-reactive protein and other circulating markers of inflamma-tion in the prediction of coronary heart disease.N. Engl. J.Med.2004,350, 1387–1397.
• [11] Sidney, C., Smith, J., Anderson, J. L., Cannon, R. O.et al.,CDC/AHA Workshop on Markers of Inflammation and Cardi-ovascular Disease Application to Clinical and Public HealthPractice: Report from the Clinical Practice Discussion Group.Circulation2004,110, e550–e55.
• [12] Mayr, M., Mayr, U., Chung, Y. L., Yin, X.et al., Vascular pro-teomics: Linking proteomic and metabolomic changes.Pro-teomics2004,4, 3751–3761.
• [13] Marian, A. J., Nambi, V., Biomarkers of cardiac disease.Expert Rev. Mol. Diagn.2004,4, 805–820.
• [14] Glass, C. K., Witzum, J. L., Atherosclerosis: The road ahead.Cell2001,104, 503–516.
• [15] Hanson, G. K., Inflammation, atherosclerosis, and coronaryartery disease.N. Engl. J. Med.2005,352, 1685–1695.
• [16] Wasserman, E., Shipley, N. M., Atherothrombosis in acutecoronary syndromes: Mechanisms, markers and mediatorsof vulnerability.Mount Sin. J. Med.2006,73, 431–439.
• [17] Vivanco, F. (Ed.),Cardiovascular Proteomics. Methods andProtocols, Humana Press, Totowa, New Jersey 2007,Vol.357.
• [18] Arab, S., Gramolini, A. O., Ping, P., Kislinger, T., Stanley, B.,Cardiovascular proteomics.J. Am. Coll. Cardiol.2006,48,1733–1741.
• [19] Vivanco, F., Darde, V. M., De la Cuesta, F., Barderas, M. G.,Cardiovascular proteomics.Curr. Proteomics2006,3, 147–170.
• [20] Hwang, S. I., Thumar, J., Lundgren, D. H., Rezaul, K.et al.,Direct cancer tissue proteomics: A method to identify can-didate cancer biomarkers from formalin-fixed parrafin-embebed archival tissues.Oncogene2007,26, 65–76.
• [21] Bagnato, C., Thumar, J., Mayya, V., Hwang, S. I.et al., Pro-teomic analysis of human coronary atherosclerotic plaque:A feasibility study of direct tissue proteomics by liquid-chromatography and tandem mass spectrometry.Mol. Cell.Proteomics2007,6, 1088–1102.
• [22] Talusan, P., Bedri, S., Yang, S., Kattapuram, T.et al., Analysisof intimal proteoglycans in atherosclerosis-prone andatherosclerosis-resistant human arteries by mass spec-trometry.Mol. Cell Proteomics2005,4, 1350–1357.
• [23] Mayr, M., Chung, Y. L., Mayr, U., Yin, X.et al., Proteomic andmetabolomic analyses of atherosclerotic vessels from apo-lipoprotein E deficient mice reveal alterations in inflamma-tion, oxidative stress, and energy metabolism.Arterioscler.Thromb. Vasc. Biol.2005,25, 2135–2142.
• [24] Martinet, W., Schrijvers, D. M., De Meyer, G. R., Herman, A.G., Kockx, M. M., Western array analysis of human athero-sclerotic plaques. Down regulation of apoptosis-linked gene2.Cardiovasc. Res.2003,60, 259–267.
• [25] Martinet, W., Western array analysis of human athero-sclerotic plaques.Methdods Mol. Biol.2006,357, 165–178.
• [26] Donners, M., Verluyten, M. J., Bouwman, F. G., Mariman, E.et al., Proteomic analysis of differential protein expressionin human atherosclerotic plaque progression.J. Pathol.2005,206, 39–45.
• [27] Hilker, M., Buerke, M., Guckenbiehl, M., Schwertz, H.et al.,Rapamycin reduces neointima formation during vascularinjury.VASA2003,32, 10–13.
• [28] Slevin, M., Elasbali, A. B., Turu, M., Krupinski, J.et al., Iden-tification of differential protein expresión associated withdevelopment of unstable human carotid plaques.Am. J.Pathol.2006,168, 1004–1021.
• [29] Durán, M. C., Mas, S., Martin-Ventura, J. L., Meilhac, O.et al.,Proteomic analysis of human vessels: Application to ather-osclerotic plaques.Proteomics2003,3, 973–978.
• [30] Durán, M. C., Martin-Ventura, J. L., Mohammed, S., Barderas, M. G.et al., Atorvastatin modulates the profile ofproteins released by human atherosclerotic plaques.Eur. J.Pharmacol.2007,562, 119–129.
• [31] Duran, M. C., Martín-Ventura, J. L., Mas, S., Barderas, M. G.et al., Characterization of the human atheroma plaquesecretome by proteomic analysis.Methods Mol. Biol.2006,357, 141–150.
• [32] Vivanco, F., Martin-Ventura, J. L., Duran, M. C., Barderas, M.G.et al., Quest for novel cardiovascular biomarkers by pro-teomic analysis.J. Proteome Res.2005,4, 1181–1191.
• [33] Blanco-Colio, L., Martín-Ventura, J. L., Vivanco, F., Michel, J.B.et al., Biology of atherosclerotic plaques: What we arelearning from proteomic analysis.Cardiovasc. Res.2006,72,18–29.
• [34] Martín-Ventura, J. L., Duran, M. C., Blanco-Colio, L., Meilhac,O.et al., Identification by a differential proteomic approachof heat shock protein 27 as a potential marker of athero-sclerosis.Circulation2004,110, 2216–2219.
• [35] Martin-Ventura, J. L., Nicolas, V., Houard, X., Blanco-Colio, L.et al., Biological significance of decreased HSP27 in humanatherosclerosis.Arterioscler. Thromb. Vasc. Biol.2006,26,1337–1343.
• [36] Galis, Z. S., Sukhova, G. K., Lark, M. W., Libby, P., Increasedexpression of matrix metalloproteinases and matrixdegrading activity in vulnerable regions of human athero-sclerotic plaques.J. Clin. Invest.1994,94, 2493–2503.
• [37] Lijnen, H. R., Plasmin and matrix metalloproteinases in vas-cular remodelling.Thromb. Haemost.2001,86, 324–333.
• [38] Fogari, R., Derosa, G., Lazzari, P., Zoppi, A.et al., Effect ofamlodipine-atorvastatin combination on fibrinolysis inhypertensive hypercholesterolemic patients with insulinresistance.Am. J. Hypertens.2004,17, 823–827.
• [39] Martin-Ventura, J. L., Tuñon, J., Duran, M. C., Blanco-Colio,L.et al., Vascular protection of dual therapy (atorvastatin-amlodipine) in hypertensive patients.J. Am. Soc. Nephrol.2006,17, S189–S193.
• [40] Dupont, A., Corseaux, D., Dekeyzer, O., Drobecq, H.et al.,The proteome and secretome of human arterial smoothmuscle cells.Proteomics2005,5, 585–596.
• [41] Dupont, A., Pinet, F., The proteome and secretome of humanarterial smooth muscle cells.Methods Mol. Biol.2006,357,225–233.
• [42] Liao, D. F., Jin, Z. G., Baas, A. S., Daum, G.et al., Purificationand identification of secreted oxidative stress-induced fac-tors from vascular smooth muscle cells.J. Biol. Chem.2000,275, 189–196.
• [43] Dupont, A., Tokarski, C., Dekeyzer, O., Guihot, A. L.et al.,Two-dimensional maps and databases of the human mac-rophage proteome and secretome.Proteomics2004,4,1761–1778.
• [44] Fach, E. M., Garulacan, L., Gao, J., Xiao, Q.et al., In vitrobiomarker discovery for atherosclerosis by proteomics.Mol.Cell. Proteomics2004,3, 1200–1210.
• [45] Rajala, M. W., Scherer, P. E., Minireview: The adipocyte–atthe crossroads of energy homeostasis, inflammation, andatherosclerosis.Endocrinology2003,144, 3765–3773.
• [46] Chen, X., Cushman, S. W., Pannell, L. K., Hess, S., Quantita-tive proteomic analysis of the secretory proteins from ratadipose cells using a 2D liquid chromatography-MS/MSapproach.J. Proteome Res.2005,4, 570–577.
• [47] Wang, P., Mariman, E., Keijer, J., Bouwman, F.et al., Profilingof the secreted proteins during 3T3-L1 adipocyte differ-entiation leads to the identification of novel adipokines.Cell.Mol. Life Sci.2004,61, 2405–2417.
• [48] Kratchmarova, I., Kalume, D. E., Blagoev, B., Scherer, P. E.etal., A proteomic approach for identification of secreted pro-teins during the differentiation of 3T3-L1 preadipocytes toadipocytes.Mol. Cell. Proteomics2002,1, 213–222.
• [49] Alvarez-Llamas, G., Szalowska, E., de Vries, M. P., Weening,D.et al., Characterization of the human visceral adipose tis-sue secretome.Mol. Cell. Proteomics, 2007,6, 589–600.
• [50] Caprioli, R. M., Farmer, T. B., Gile, J., Molecular imaging ofbiological samples: Localization of peptides and proteinsusing MALDI-TOF MS.Anal. Chem.1997,69, 4751–4760.
• [51] Stoeckli, M., Chaurand, P., Hallahan, D. E., Caprioli, R. M.,Imaging mass spectrometry: A new technology for theanalysis of protein expression in mammalian tissues.Nat.Med.2001,7, 493–496.
• [52] Brunelle, A., Touboul, D., Laprevote, O., Biological tissueimaging with time-of-flight secondary ion mass spectrome-try and cluster ion sources.J. Mass Spectrom.2005,40, 985–999.
• [53] Wiseman, J. M., Ifa, D. R., Song, Q., Cooks, R. G., Tissue im-aging at atmospheric pressure using desorption electro-spray ionization (DESI) mass spectrometry.Angew Chem.Int. Ed. Engl.2006,45, 7188–7192.
• [54] Chaurand, P., Norris, J., Cornett, S., Mobley, J. A., Caprioli,R., New developments in profiling and imaging of proteinsfrom tissue sections by MALDI mass spectrometry.J. Pro-teome Res.2006,5, 2889–2900.
• [55] Stoeckli, M., Knochenmuss, R., McCombie, G., Mueller, D.etal., MALDI MS imaging of amyloid.Methods Enzymol.2006,412, 94–106.
• [56] Han, J., Schey, K. L., MALDI tissue imaging of ocular lensalpha-crystallin.Invest. Ophthalmol. Vis. Sci.2006,47, 2990–2996.
• [57] Meistermann, H., Norris, J. L., Aerni, H. R., Cornett, D. S.etal., Biomarker discovery by imaging mass spectrometry:Transthyretin is a biomarker for gentamicin-inducednephrotoxicity in rat.Mol Cell. Proteomics2006,5, 1876–1886.
• [58] Roy, S., Touboul, D., Brunelle, A., Germain, D. P.et al.,Im-aging mass spectrometry: A new tool for the analysis of skinbiopsy. Application in Fabry’s disease.Ann. Pharm. Fr.2006,64, 328–334.
• [59] Mas, S., Toubul, D., Brunelle, A., Aragoncillo, P.et al., Lipidcartography of atherosclerotic plaque by cluster TOF SIMSimaging. Analyst2007,132, 24–26.
• [60] Malmberg, P., Borner, K., Chen, Y., Friberg, P.et al., Localiza-tion of lipids in the aortic wall with imaging TOF-SIMS.Bio-chim. Biophys. Acta2007,1771, 185–195.
• [61] Watson, A. D., Thematic review series: Systems biologyapproaches to metabolic and cardiovascular disorders.Lipidomics: A global approach to lipid analysis in biologicalsystems.J. Lipid Res.2006,47, 2101–2111.
• [62] Touboul, D., Brunelle, A., Laprevote, O., Structural analysisof secondary ions by post-source decay in time-of-flightsecondary ion mass spectrometry.Rapid Commun. MassSpectrom.2006,20, 703–709.
• [63] De Caterina, R., Endothelial dysfunctions: Commondenominators in vascular disease.Curr. Opin. Lipidol.2000,11, 9–23.
• [64] Blann, A. D., Assessment of endothelial dysfunction: Focuson atherothrombotic disease.Pathophysiol. Haemost.Thromb.2004,33, 256–261.
• [65] Gonzalez-Cabrero, J., Pozo, M., Duran, M. C., De Nicolas, R.et al., The proteome of endotelial cells.Methods Mol. Biol.2006,357, 181–198.
• [66] Brunneel, A., Labas, V., Mailloux, A., Sharma, S.et al., Pro-teomic study of human umbilical vein endothelial cells inculture.Proteomics2003,3, 714–723.
• [67] Kamino, H., Hiratsuka, M., Toda, T., Nishigaki, R.et al.,Searching for genes involved in arteriosclerosis: Proteomicanalysis of cultured human umbilical vein endotelial cellsundergoing replicative senescence.Cell Struct. Funct.2003,28, 495–503.
• [68] Kinumi, T., Ogawa, Y., Kimata, J., Saito, Y.et al., Proteomiccharacterization of oxidative dysfunction in human umbili-cal vein endothelial cells (HUVEC) induced by exposure tooxidized LDL.Free Rad. Res.2005,39, 1335–1344.
• [69] Sprenger, R. R., Speijer, D., Back, J. W., De Coster, C. G.et al.,Comparative proteomics of human endothelial cell caveolaeand rafts using two-dimensional gel electrophoresis andmass spectrometry.Electrophoresis2004,25, 156–172.
• [70] Sprenger, R. R., Horrevoets, J. G., Proteomic study ofcaveolae and rafts isolated from human endothelial cells.Methods Mol. Biol.2006,357, 199–213.
• [71] Fuchs, D., Erhard, P., Turner, R., Rimbach, G.et al., Genisteinreverses changes of the proteome induced by oxidized-LDL n Eahy 926 human endothelial cells.J. Proteome Res.2005,4, 369–376.
• [72] Clarkson, T. B., Soy, soy phytoestrogens and cardiovasculardiseases.J. Nutr.2002,132, 566S–569S.
• [73] Cassidy, A., Griffin, B., Phytooestrogens: A potential role inthe prevention of CHD?.Proc. Nutr. Soc.1999,58, 193–199.
• [74] Littlewood, T. D., Bennett, M. R., Apoptotic cell death inatherosclerosis.Curr. Opin. Lipidol.2003,14, 469–475.
• [75] Becker, R. C., Proteomics, metabolomics and circulatingendothelial progenitor cells in acute coronary syndromes.J.Thromb. Thrombolysis2006,21, 203–206.
• [76] Boos, C. J., Lip, G. Y., Blann, A. D., Circulating endothelialcells in cardiovascular diseases.J. Am. Coll. Cardiol.2006,48, 1538–1547.
• [77] Yeh, E. T., Zhang, S., Wu, H. D., Korbling, M.et al., Transdif-ferentiation of human peripheral blood CD341enriched cellpopulation into cardiomyocytes, endothelial cells, andsmooth muscle cellsin vivo.Circulation2003,108, 2070–2073.
• [78] Lee, K. W., Lip, G. Y., Tayebjee, M., Foster, W., Blann, A. D.,Circulating endothelial cells, von Willebrand factor, inter-leukin-6, and prognosis in patients with acute coronary syn-dromes.Blood2005,105, 526–532.
• [79] Werner, N., Kosiol, S., Schiegl, T., Ahlers, P.et al., Circulatingendothelial progenitor cells and cardiovascular outcomes.N. Engl. J. Med.2005,353, 999–1007.
• [80] McGregor, A., Kempster, L., Wait, R., Welson, S. Y.et al.,Identification and mapping of human saphenous vein med-ial smooth muscle proteins by two dimensional gel electro-phoresis.Proteomics2001,1, 1405–1414.
• [81] McGregor, E., Kempster, L., Wait, R., Gosling, M.et al.,F-actin capping (CapZ) and other contractile saphenous veinsmooth muscle proteins are altered by hemodynamicstress.Mol. Cell. Proteomics2004,3, 115–124.
• [82] Pellieux, C., Desgeorges, A., Pigeon, C. H., Chambaz, C.etal., CapG, a gelsolin family protein modulating protectiveeffects of unidirectional shear stress.J. Biol. Chem.2003,278, 29136–29134.
• [83] Dupont, A., Corseaux, D., Dekeyzer, O., Drobecq, H.et al.,The proteome and secretome of human arterial smoothmuscle cells.Proteomics2005,5, 585–596.
• [84] Patton, W., Erdjument-Bromage, H., Marks, A. R., Tempst, P.,Taubman, M. B., Components of the protein synthesis andfolding machinery are induced in vascular smooth musclecells by hypertrophic and hyperplastic agents.J. Biol. Chem.1995,270, 21404–21410.
• [85] Mayr, M., Siow, R., Chung, Y. L., Mayr, U.et al., Proteomicand metabolomic analysis of vascular smooth muscle cells.Role of PKCd.Circ. Res.2004,94, e87–e96.
• [86] Leitges, M., Mayr, M., Braun, U., Mayr, U.et al., Exacerbatedvein graft arteriosclerosis in protein kinase Cdelta-null mice.J. Clin. Invest.2001,108, 1505–1512.
• [87] Sukanov, S., Delafontaine, P., Protein chip-based microarrayprofiling of oxidized low density lipoprotein-treated cells.Proteomics2005,5, 1274–1280.
• [88] Yang, P. Y., Rui, Y. C., Yan, P. Y., Yu, Y. L., Proteomic analysisof foam cells.Meth. Mol. Biol.2006,357, 297–305.
• [89] Dupont, A., Tokarski, C., Dekeyzer, O., Guihot, A. L.et al.,Two-dimensional maps and databases of the human mac-rophage proteome and secretome.Proteomics2004,4,1761–1778.
• [90] Verhoeckx, K. C., Bijlsma, S., De Groene, E. M., Witkamp, R.F.et al., A combination of proteomics, principal componentanalysis and transcriptomics is a powerful tool for theidentification of biomarkers for macrophage maturation inthe U937 cell line.Proteomics2004,4, 1014–1028.
• [91] Gadgil, H. S., Pabst, K. M., Giorgianni, F., Umstot, E. S.etal., Proteome of monocytes primed with lipopolysacchar-ide: Analysis of the abundant proteins.Proteomics2003,3,1767–1780.
• [92] Rakkola, R., Matikainen, S., Nyman, T. A., Proteome analy-sis of human macrophages reveals the upregulation ofmanganese-containing superoxide dismutase after toll-likereceptor activation.Proteomics2007,7, 378–384.
• [93] Yu, Y., Yang, P., Rui, Y., Yang, P., Proteomic studies of mac-rophage derived foam cell from human U937 cell line usingtwo-dimensional gel electrophoresis and tandem massspectrometry.J. Cardiovasc. Pharmacol.2003,42, 782–789.
• [94] Yu, Y., Yang, P. Y., Fan, H. Z., Huang, Z. Y.et al., Proteinexpression in macrophage derived foam cells: Compara-tive analysis by two-dimensional gel electrophoresis.ActaPharmacol. Sin.2003,24, 873–877.
• [95] Kang, J. H., Kim, H. T., Choi, M., Lee, W.et al., Proteomeanalysis of human monocytic THP-1 cells primed with oxi-dized low-density lipoproteins.Proteomics2006,6, 1261–1273.
• [96] Tuomisto, T. T., Riekkinen, M. S., Viita, H., Levonen, A. L.,Ylä-Herttuala, S., Analysis of gene and protein expresiónduring monocyte-macrophage differentiation and choles-terol loading cDNA and protein array study.Athero-sclerosis2005,180, 283–291.
• [97] Tuomisto, T. T., Binder, B. R., Ylä-Herttuala, S., Genetics,genomics and proteomics in atherosclerosis research.Ann. Med.2005,37, 323–332.
• [98] Conway, J. P., Kinter, M., Proteomic and transcriptomicanalyses of macrophages with an increased resistance tooxidized low density lipoprotein (oxLDL) induced citotoxi-city generated by chronic exposure to oxLDL.Mol. Cell.Proteomics2005,4, 1522–1540.
• [99] Bobryshev, Y. V., Lord, R. S., Parsson, H., Immunopheno-typic analysis of the aortic aneurysm wall suggests thatvascular dendritic cells are involved in immune responses.Cardiovasc. Surg.1998,6, 240–249.
• [100] Bobryshev, Y. V. Dendritic cells and their involvement inatherosclerosis,Curr. Opin. Lipidol.2000,11, 511–517.
• [101] Yilmaz, A., Lochno, M., Traeg, F., Cicha, I.et al., Athero-sclerosis: Emergence of dendritic cells in rupture-proneregions of vulnerable carotid plaques.Atherosclerosis2004,176, 101–110.
• [102] Phipps, R. P., Atherosclerosis: The emerging role ofinflammation and the CD40-CD40 ligand system.Proc.Natl. Acad. Sci. USA2000,97, 6930–6932.
• [103] Rivollier, A., Perrin-Cocon, L., Luches, S., Diemer, H.et al.,High expression of antioxidant proteins in dendritic cells.Possible implications in atherosclerosis. Mol. Cell. Prote-omics2006,5, 726–736.
• [104] Anderson, N. L., Anderson, N. G., The human plasma protein.Mol. Cell. Proteomics2002,1, 845–867
• ]105] Righetti, P. G., Castagna, A., Antonioli, P., Boschetti, E.,Prefractionation techniques in proteome analysis: Themining tools of the third millennium.Electrophoresis2005,26, 297–319.
• [106] Zhang, H., Liu, A. Y., Loriaux, P., Wollscheid, B.et al., Massspectrometric detection of tissue proteins in plasma.Mol.Cell. Proteomics2007,6, 64–71.
• [107] Berhane, B. T., Zong, C., Liem, D. A., Huang, A.et al., Car-diovascular-related proteins identified in human plasma bythe HUPO plasma proteome project pilot phase.Proteom-ics2005,5, 3520–3530.
• [108] Anderson, L., Candidate-based proteomics in the searchfor biomarkers of cardiovascular diseases.J. Physiol.2005,563.1, 23–60.
• [109] Mateos-Caceres, P. J., Garcia-Mendez, A., Lopez-Farre, A.,Macaya, C.et al., Proteomic analysis of plasma frompatients during an acute coronary syndrome.J. Am. Coll.Cardiol.2004,44, 1578–1583.
• [110] Alonso-Orgaz, S., Moreno, L., Macaya, C., Rico, L.et al.,Proteomic study of plasma from moderate hypercholes-terolemic patients.J. Proteome Res.2006,5, 2301–2308.
• [111] Tabibiazar, R., Wagner, R. A., Deng, A., Tsao, P. S., Querte-mous, T., Proteomic profiles of serum inflammatory mark-ers accurately predict atherosclerosis in mice.Physiol.Genomics2006,25, 194–202.
• [112] Di Serio, F., Amodio, G., Ruggieri, E., De Sario, R.et al.,Proteomic approach to the diagnosis of acute coronarysyndrome: Preliminary results.Clin. Chim. Acta2005,357,226–235.
• [113] Abdul-Salam, V. B., Paul, G. A., Ali, J. O., Gibb, S. R.et al.,Identification of plasma protein biomarkers associatedwith idiopathic pulmonary arterial hypertension.Proteom-ics2006,6, 2286–2294.
• [114] Diamandis, E., Serum proteomic profiling by matrix-assis-ted laser desorption-ionization time of flight mass spec-trometry for cancer diagnosis: Next steps.Cancer Res.2006,66, 5540–5541.
• [115] Darde, V. M., Barderas, M. G., Vivanco, F., Depletion ofhigh-abundance proteins in plasma by immunoaffinitysubtraction for two-dimensional difference gel electropho-resis analysis.Methods Mol. Biol.2006,357, 351–364.
• [116] Fu, Q., Bovenkamp, D. E., Van Eyk, J. E., A rapid, econom-ical, and reproducible method for human serum delipida-tion and albumin and IgG removal for proteomic analysis.Methods Mol. Biol.2006,357, 365–371.
• [117] Marshall, J., Kupchak, P., Zhu, W., Yantha, J.et al., Proces-sing of serum proteins underlies the mass spectral finger-printing of myocardial infarction.J. Proteome Res.2003,2,361–372.
• [118] Villanueva, J., Shaffer, D. R., Philip, J., Chapparro, C. A.etal., Differential exoprotease activities confer tumor-specificserum peptidome patterns.J. Clin. Invest.2006,116, 271–284.
• [119] Hortin, G. L., The MALDI-TOF mass spectrometric view ofthe plasma proteome and peptidome.Clin. Chem.2006,52,1218–1222.
• [120] Petricoin, E. F., Belluco, C., Araujo, R. P., Liotta, L. A., Theblood peptidome: A higher dimension of information con-tent for cancer biomarker discovery.Nat. Rev. Cancer2006,6, 961–967.
• [121] Hwang, I. K., Park, S. M., Kim, S. Y., Lee, S. T., A proteomicapproach to identify substrates of matrix metalloprotei-nase-14 in human plasma.Biochim. Biophys. Acta2004,1702, 79–87.
• [122] Kiernan, U. A., Nedelkov, D., Nelson, R. W., Multiplexesmass spectrometric immunoassay in biomarker research:A novel approach to the determination of a myocardialinfarct.J. Proteome Res.2006,5, 2928–2934.
• [123] Karlsson, H., Leanderson, P., Tagesson, C., Lindahl, M.,Lipoproteomics I: Mapping of proteins in low-density lipo-protein using two-dimensional gel electrophoresis andmass spectrometry.Proteomics2005,5, 551–565.
• [124] Karlsson, H., Leanderson, P., Tagesson, C., Lindahl, M.,Lipoproteomics II: Mapping of proteins in high-densitylipoprotein using two-dimensional gel electrophoresis andmass spectrometry.Proteomics2005,5, 1432–1445.
• [125] Rezaee, F., Casetta, B., Levels, J. H. M., Speijer, D, Meijers,J. C. M., Proteomic analysis of high-density lipoprotein.Proteomics2006,6, 721–730.
• [126] Karlsson, H., Lindquist, H., Tagesson, C., Lindahl, M., Char-acterization of apolipoprotein M isoforms in low-densitylipoprotein.J. Proteome Res.2006,6, 2685–2690.
• [127] Mancone, C., Amicone, L., Fimia, G. M., Bravo, E.et al.,Proteomic analysis of human very low density lipoproteinsby two-dimensional gel electrophoresis and MALDI-TOF/TOF.Proteomics2007,7, 143–154.
• [128] Heller, M., Schlappritzi, A., Stalder, D., Nuoffer, J. M.et al.,Compositional protein analysis of high-density lipoproteinin hypercolesterolemia by shotgun LC-MS/MS and prob-abilistic peptide score.Mol. Cell. Proteomics2007,6, 1059–1072.
• [129] Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A.et al.,Shotgun proteomics implicates protease inhibition andcomplement activation in the antiinflammatory propertiesof HDL.J. Clin. Invest.2007,117, 746–756.
• [130] Osterud, B., Bjorklid, E., Role of monocytes in atherogen-esis.Physiol. Rev.2003,83, 1089–10112.
• [131] Wasserman, E., Shipley, N. M., Atherothrombosis in acutecoronary syndromes: Mechanisms, markers and mediatorsof vulnerability.Mount Sin. J. Med.2006,73, 431–439.
• [132] Llodrá, J., Angeli, V., Liu, J., Trogan, E.et al., Emigration ofmonocyte-derived cells from atherosclerotic lesions char-acterizes regressive, but not progressive, plaques.Proc.Natl. Acad. Sci.2004,101, 11779–11784.
• [133] Barderas, M. G., Gallego-Delgado, J., Mas, S., Durán, M. C.et al., Isolation of circulating human monocytes with highpurity for proteomic analysis.Proteomics2004,4, 432–437.
• [134] Barderas, M. G., Darde, V. M., Duran, M. C., Egido, J.,Vivanco, F., Characterization of circulating human mono-cytes by proteomic analysis.Methods Mol. Biol.2006,357,319–328.
• [135] Barderas, M. G., Tuñón, J., Dardé, V. M., De la Cuesta, F.etal., Circulating human monocytes in the acute coronarysyndromes express a characteristic profile.J. Proteom.Res.2007,2, 876–886.
• [136] Hakala, J. K, Oksjoki, R., Laine, P., Du, H.et al., Lysosomalenzymes are released from cultured human macrophages,hydrolyze LDLin vitro, and are present extracellularly inhuman atherosclerotic lesions.Arterioscler. Thromb. Vasc.Biol.2003,23, 1430–1436
• [137] Marcus, K., Meyer, H. E., Two dimensional polyacrylamidegel electrophoresis for platelet proteomics.Methods Mol.Biol.2004,273, 421–434.
• [138] O’Neil, E. E., Brock, C. J., von Kriegsheim, A. F., Pearce, A.C.et al., Towards complete analysis of platelet proteome.Proteomics2002,2, 288–305.
• [139] Garcia, A., Zitzmann, N., Watson, S. P., Analysing theplatelet proteome.Semin. Thromb. Hemost.2004,30, 485–489.
• [140] McRedmond, J. P., Park, S. D., Reilly, D. F., Coppinger, J.etal., Integration of proteomics and genomics in platelets. Aprofile of platelet proteins and platelet specific genes.Mol.Cell. Proteomics2004,3, 133–144.
• [141] Martens, L., Van Damme, P., Van Dame, J., Staes, A.et al.,The human platelet proteome mapped by peptide-centricproteomics: A functional protein profile.Proteomics2005,5, 3193–3204.
• [142] Zellner, M., Winkler, W., Hayden, H., Diestinger, M.et al.,Quantitative validation of different protein precipitationmethods in proteome analysis of blood platelet.Electro-phoresis2005,26, 2481–2489.
• [143] Gevaert, K., Eggermont, L., Demol, H., Vandekerckhove, J.,A fast and convenient MALDI-MS based proteomicapproach: Identification of components scaffolded by theactin cytoskeleton of activated human thrombocytes.J.Biotechnol.2000,78, 259–269.
• [144] Garcia, A., Prabhakar, S., Brock, C. J., Pearce, A. C., Dwek,R. A., Extensive analysis of the human platelet proteome bytwo-dimensional gel electrophoresis and mass spectrom-etry.Proteomics2004,4, 656–658.
• [145] Immler, D., Gremm, D., Kirsch, D., Spengler, B.et al., Iden-tification of phosphorylated proteins from thrombin-acti-vated human platelets isolated by two-dimensional gelelectrophoresis by electrospray ionization tandem massspectrometry (ESI-MS/MS) and liquid chromatographyelectrospray ionization mass spectrometry (LC-ESI-MS).Electrophoresis1998,19, 1015–1023.
• [146] Maguire, P. B., Wynne, K. J., Harney, D. F., O’Donoghue, N.M.et al., Identification of the phosphotyrosine proteomefrom thrombin activated platelets.Proteomics2002,2, 642–648.
• [147] Foy, M., Harney, D. F., Wynne, K., Maguire, P. B., Enrich-ment of phosphotyrosine proteome of human platelets byimmunoprecipitation.Methods Mol. Biol.2007,357, 313–318.
• [148] Marcus, K., Moebius, J., Meyer, H. E., Differential analysisof phosphorylated proteins in resting and thrombin stimu-lated human platelets.Anal. Bioanal. Chem.2003,376, 973–993.
• [149] Zahedi, R. P., Begonja, A. J., Gambarayan, S., Sickman, A.,Phosphoproteomics of human platelets: A request fornovel activation pathways.Biochim. Biophys. Acta2006,1764, 1963–1976.
• [150] Senis, Y. A., Tomlinson, M. G., Garcia, A., Dumen, S.et al.,A comprehensive proteomics and genomics analysisreveals novel transmembrane proteins in human plateletsand mouse megakaryocytes including G6b, a novel ITMprotein.Moll. Cell. Proteomics2007,6, 548–564.
• [151] Gevaert, K., Goethals, M., Martens, L., Van Damme, J.et al.,Exploring proteomes and analyzing protein processing bymass spectrometric identification of sorted N-terminalpeptides.Nat. Biotechnol.2003,21, 566–569.
• [152] Garcia, A., Prabhakar, S., Hughan, S., Anderson, T. W.et al.,Differential proteome analysis of TRAP-activated platelets:Involvement of Dok-2 and phosphorylation of RGS pro-teins.Blood2004,103, 2088–2095.
• [153] Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T.et al.,Characterization of the proteins released from activatedplatelets leads to localization of novel platelet proteins inhuman atherosclerotic lesions.Blood2004,103, 2096–2104.
• [154] Coppinger, J., Fitzgerald, D. J., Maguire, P. B., Isolation ofthe platelet releasate.Methods Mol. Biol.2006,357, 307–311.
• [155] Macaulay, I. C., Carr, P., Gusnanto, A., Ouwehand, W. H.etal., Platelet genomics and proteomics in human health anddisease.J. Clin. Invest.2005,115, 3370–3377.
• [156] Dittrich, M., Birschmann, I., Stuhfelder, C., Sickmann, A.etal., Understanding platelets. Lessons from proteomics,genomics and promises from network analysis.Thromb.Haemost.2005,94, 916–925.
• [157] Maguire, P. B., Fitzgerald, D. J., Platelet proteomics.J.Thromb. Haemost.2003,1, 1593–1601.
• [158] Moebius, J., Zahedi, R. P., Lewandroski, U., Berger, C.et al.,The human platelet membrane proteome reveals severalnew potential membrane proteins.Mol. Cell. Proteomics2005,4, 1754–1761.
• [159] Lewandroski, U., Moebius, J., Walter, U., Sickmann, A.,Elucidation of N-glycosylation sites on human plateletproteins. A glycoproteomic approach.Mol. Cell. Proteom-ics2006,5, 226–233.
• [160] Weyrich, A. S., Zimmerma, G. A., Propelling the plateletproteome.Blood2004,103, 1979.
• [161] Garcia, A., Watson, S. P., Dwek, R. A., Zitzmann, N., Apply-ing proteomics technology to platelet research.MassSpectrom. Rev.2005,24, 918–930.
• [162] Maguire, P. B., Moran, N., Cagney, G., Fitzgerald, D., Appli-cation of proteomics to study of platelet regulatory mech-anisms.Trends Cardiovasc. Med.2004,14, 207–220.
• [163] Garcia, A., Watson, S. P., Dwek, R. A., Zitzmann, N., Apply-ing proteomics technology to platelet research.MassSpectrom. Rev.2005,24, 918–930.
• [164] Gnatenko, D. V., Perrota, P. L., Bahou, W. F., Proteomicapproaches to dissect platelet function: Half the story.Blood2006,108, 3983–3991.
• [165] Wang, X., Zhao, H., Anderson, R., Proteomics and leuko-cytes: An approach to understanding potential molecularmechanism of inflammatory responses.J. Proteome Res.2004,3, 921–929.
• [166] Madjid, M., Awan, I., Willerson, J. T., Casscells, S. W., Leu-kocyte count and coronary heart disease: Implications forrisk assessment.J. Am. Coll. Cardiol.2004,44, 1945–1956.
• [167] Naruko, T., Ueda, M., Haze, K., Van der Wal, A. C.et al.,Neutrophil infiltration of culprit lesions in acute coronarysyndromes.Circulation2002,106, 2894–2900.
• [168] Fessler, M. B., Malcolm, K. C., Duncan, M. W., Worthen, G.S., A genomic and proteomic analysis of activation of thehuman neutrophil by lipopolysaccharide and its mediationby p38 mitogen-activated protein kinase.J. Biol. Chem.2002,277, 31291–302.
• ]169] Boussac, M., Garin, J., Calcium-dependent secretion inhuman neutrophils: A proteomic approach.Electrophore-sis2000,21, 665–672.
• [170] Lominadze, G., Powell, D. W., Luerman, G. C., Link, A. J.etal., Proteomic analysis of human neutrophil granules.Mol.Cell. Proteomics2005,4, 1503–1521.
• [171] Lominadze, G., Ward, R. A., Klein, J. B., McLeisch, K. R.,Proteomic analysis of human neutrophils.Methods Mol.Biol.2006,332, 343–356.
• [172] Kakhniashvili, D. G., Bulla, L. A., Goodman, S. R., The hu-man erythrocyte proteome. Analysis by ion trap massspectrometry.Mol. Cell. Proteomics2004,3, 501–509.
• [173] Low, T. Y., Seow, T. K., Chung, M. C. M., Separation of hu-man erythrocyte membrane associated proteins with onedimensional and two-dimensional gel electrophoresis fol-lowed by identification with matrix assisted laser desorp-tion/ionisation time of flight mass spectrometry.Proteom-ics2002,2, 1229–1239.
• [174] Luche, S., Santoni, V., Rabilloud, T., Evaluation of nonioniczwitterionic detergent as membrane protein solubilizers intwo-dimensional electrophoresis.Proteomics2003,3, 249–253.
• [175] Bruschi, M., Seppi, C., Arena, S.et al., Proteomic analysisof erythrocyte membranes by soft immobiline gels com-bined with differential protein extraction.J. Proteome Res.2005,4, 1304–1309.
• [176] Tyan, Y. C., Jong, S. B., Liao, P. C., Yang, M. H.et al., Prote-omic profiling of erythrocyte proteins by proteolytic diges-tion chip and identification using two-dimensional electro-spray ionisation tandem mass spectrometry.J. ProteomeRes.2005,4, 748–757.
• [177] Kakhniashvili, D. G., Griko, N. B., Bulla, L. A., Goodman, S.R., The proteomics of sickle cell disease: Profiling of eryth-rocyte membrane proteins by 2D-DIGE and tandem massspectrometry.Exp. Biol. Med.2005,230, 787–792.
• [178] Pasini, E. M., Kirkegaard, M., Mortensen, P., Lutz, H. U.etal., In-depth analysis of the membrane and cytosolic pro-teome of red blood cells.Blood2006,108, 791–801.
• [179] Queloz, P. A., Thadikkaran, L., Crettaz, D., Rossier, J. S.etal., Proteomics and transfusion medicine: Future perspec-tives.Proteomics2006,6, 5605–5614.