Postnatal undernutrition delays a key step in the maturation of hypothalamic feeding circuits

  1. Juan de Solis, Alain
  2. Baquero, Arian F.
  3. Bennett, Camdin M.
  4. Grove, Kevin L.
  5. Zeltser, Lori M.
Revista:
Molecular Metabolism

ISSN: 2212-8778

Ano de publicación: 2016

Volume: 5

Número: 3

Páxinas: 198-209

Tipo: Artigo

DOI: 10.1016/J.MOLMET.2016.01.003 GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Molecular Metabolism

Obxectivos de Desenvolvemento Sustentable

Resumo

Objective: Humans and animals exposed to undernutrition (UN) during development often experience accelerated “catch-up” growth when foodsupplies are plentiful. Little is known about the mechanisms regulating early growth rates. We previously reported that actions of leptin andpresynaptic inputs to orexigenic NPY/AgRP/GABA (NAG) neurons in the arcuate nucleus of the hypothalamus are almost exclusively excitatoryduring the lactation period, since neuronal and humoral inhibitory systems do not develop until after weaning. Moreover, we identified a criticalstep that regulates the maturation of electrophysiological responses of NAG neurons at weaning e the onset of genes encoding ATP-dependentpotassium (KATP) channel subunits. We explored the possibility that UN promotes subsequent catch-up growth, in part, by delaying the maturationof negative feedback systems to neuronal circuits driving food intake.Methods: We used the large litter (LL) size model to study the impacts of postnatal UN followed by catch-up growth. We evaluated the maturationof presynaptic and postsynaptic inhibitory systems in NAG neurons using a combination of electrophysiological and molecular criteria, inconjunction with leptin’s ability to suppress fasting-induced hyperphagia.Results: The onset of KATP channel subunit expression and function, the switch in leptin’s effect on NAG neurons, the ingrowth of inhibitoryinputs to NAG neurons, and the development of homeostatic feedback to feeding circuits were delayed in LL offspring relative to controls. Thedevelopment of functional KATP channels and the establishment of leptin-mediated suppression of food intake in the peri-weaning period weretightly linked and were not initiated until growth and adiposity of LL offspring caught up to controls.Conclusions: Our data support the idea that initiation of KATP channel subunit expression in NAG neurons serves as a molecular gatekeeper forthe maturation of homeostatic feeding circuits

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