Protocolo diagnóstico de las canalopatías

  1. Rubio Campal, J.M. 1
  2. Sánchez Borque, P. 1
  3. Bravo Calero, L. 1
  4. Miracle Blanco, A. 1
  5. Porta Sánchez, A. 2
  6. Cabrera Rodríguez, J.A. 2
  1. 1 Servicio de Cardiología, Hospital Universitario Fundación Jiménez Díaz. Universidad Autónoma de Madrid, Madrid, España
  2. 2 Servicio de Cardiología, Hospital Universitario Quirónsalud Madrid. Universidad Europea de Madrid. Pozuelo de Alarcón, Madrid, España
Journal:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Year of publication: 2021

Issue Title: Enfermedades cardiovasculares (XI)

Series: 13

Issue: 45

Pages: 2653-2655

Type: Article

DOI: 10.1016/J.MED.2021.11.007 DIALNET GOOGLE SCHOLAR

More publications in: Medicine: Programa de Formación Médica Continuada Acreditado

Abstract

Channelopathies are a set of anomalies that affect cellular ion channels. Although they can be acquired, those which are most cardiologically relevant are of genetic origin. They affect certain channels of the myocytes or the specific cardiac conduction system. Although their prevalence may not be very high, their clinical repercussions are very important, because most of them are associated with the onset of polymorphic ventricular tachycardias and sudden death, many times in children and young adults. The baseline ECG has a key diagnostic role as it is the phenotypic/electrical expression of the affected channels, giving rise on many occasions to anomalies in the J point, ST segment, T wave, or QT interval. The diagnosis of the affected genes is another key element in its management, given the possible familial repercussions. Therapeutic management can be both primary, for preventing lethal arrhythmic events, and secondary, if the patient has survived one. For many, an implantable automatic defibrillator is a first-line indication.

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Data source: Dialnet