Association of changes in lysophosphatidylcholine metabolism and in microsomal membrane lipid composition to the pulmonary injury induced by oleic acid.
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Cristina Casals
12
- Luz Herrera 12
- Pedro García-Barreno 12
- Angel M.Municio 12
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1
Universidad Complutense de Madrid
info
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2
Hospital General Universitario Gregorio Marañón
info
ISSN: 0006-3002
Argitalpen urtea: 1990
Alea: 1023
Zenbakia: 2
Orrialdeak: 290-293
Mota: Artikulua
Beste argitalpen batzuk: Biochem Biophys Acta
Laburpena
Alterations in the lipid composition of lung microsomal membranes occur in oleic acid-induced respiratory distress. The marked decrease in the phosphatidylcholine/lysophosphatidylcholine molar ratio could be related with an altered metabolism of lysophosphatidylcholine in these membranes. Results revealed that the activity of phospholipase A increased whereas that of acyl-CoA:lysophosphatidylcholine acyltransferase decreased. Microsomal lysophospholipase activity remained unchanged. On the other hand, the microsomal enzyme system involved in the de novo synthesis of diacylglycerol was impaired, and cholinephosphotransferase activity was lowered. These changes in the activity of some membrane-bound enzymes were not caused by changes in the membrane lipid fluidity since lipid structural order parameter () did not change and neither did the major factors on which the fluidity depends. The possible significance of microsomal lipid alterations in the pathogenesis of respiratory distress induced by oleic acid is discussed.
Finantzaketari buruzko informazioa
This work was supported by the Grant PR84-0490 from the Comisión Asesora de Investigación Científica y Técnica.Finantzatzaile
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Comisión Asesora de Investigación Científica y Técnica
Spain
- Grant PR84-0490
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