Characterization of graphene oxide doped with metal nanoparticles and its intrisic antimicrobial properties
- A. Benito Alonso 1
- A. Tobajas Guardia 1
- A. Cerpa Naranjo 1
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1
Universidad Europea de Madrid
info
Editorial: Jesús Salido Tercero ; Ma del Milagro Fernández Carrobles ; Óscar Déniz Suárez ; Ma Gloria Bueno García
ISBN: 978-84-09-06253-9
Año de publicación: 2018
Páginas: 323-326
Congreso: Congreso Anual de la Sociedad Española de Ingeniería Biomédica CASEIB (36. 2018. Ciudad Real)
Tipo: Aportación congreso
Resumen
Nanomaterials and nanoparticles have great potential in the biomedical field. Physiochemical properties of graphene oxide nanoparticles and their composites doped with metallic copper and silver were characterized by the Nanoparticle Tracking Analysis (NTA). These nanoparticle suspensions were tested on Candida albicans and Clostridium Difficile, as both microorganisms have shown antimicrobial resistance to their actual treatments. NTA results show that the more sonication time applied to a dispersion, the more stable the obtained particle size of the dispersion is as no conglomerates are formed. The biological results of Candida albicans, show that copper exhibit the best antifungal activity during the minimum inhibitory concentration (MIC). Under the same concentration and incubation conditions of Clostridium difficile, graphene oxide- copper had the highest antibacterial properties. The incubation of both pathogens in graphene oxide-copper caused the destruction of the cell integrity and therefore, cell death.