Hiperekplexia neonatalTratamiento con una formulatión oral de clonazepam

  1. Javier Sánchez-Rubio Ferrández
  2. M.C. Girón Duch
  3. F.J. Farfán Sedano
  4. Nuria Ibáñez Heras
  5. Ana Ontañón Nasarre
Zeitschrift:
Atención Farmacéutica

ISSN: 1139-7357

Datum der Publikation: 2003

Ausgabe: 5

Nummer: 5

Seiten: 310-312

Art: Artikel

Andere Publikationen in: Atención Farmacéutica

Zusammenfassung

Objective: To describe a case of neonatal hyperekplexia as well as the preparation of an oral clonazepam solution for its treatment by the pharmacy department. Methods: Starting from a commercial 2.5 mg/ml clonazepam solution, a 0.01 mg/ml clonazepam solution is prepared by means of serial dilutions. Such solution is dispensed to the patient at the hospital as well as outside in an external patient regime. A follow-up of the patient's evolution during the treatment takes place. Results: The initial dosage of 0.025 mg/kg/day produced not only a quick improvement on the patient, but also excessive somnolence. By adjusting the dosage to 0.01 mg/kg/day, it was observed an excellent tolerance and clinical evolution, reaching the point of medication removal six months from the beginning of the treatment. Conclusions: The solution proved to be effective for the treatment of this disease, although it is necessary a posologic adjustment based on the response and the tolerance