Testosterone and androgen receptor CAG repeats length genotype interaction in motor impulsiveness

  1. García, L.F. 3
  2. Aluja, A. 2
  3. Fibla, J. 2
  4. Blanch, A. 2
  5. García, O. 1
  1. 1 Universidad Europea de Madrid
    info

    Universidad Europea de Madrid

    Madrid, España

    ROR https://ror.org/04dp46240

  2. 2 Universitat de Lleida
    info

    Universitat de Lleida

    Lleida, España

    ROR https://ror.org/050c3cw24

  3. 3 Universidad Autónoma de Madrid
    info

    Universidad Autónoma de Madrid

    Madrid, España

    ROR https://ror.org/01cby8j38

Mostrar afiliaciones +
Revista:
Personality and Individual Differences

ISSN: 0191-8869

Año de publicación: 2014

Volumen: 60

Páginas: S71

Tipo: Artículo

DOI: 10.1016/J.PAID.2013.07.315 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Personality and Individual Differences

Resumen

Interactions between CAG repeat genotypes; free testosterone (FT) and sex hormone binding globulin (SHBG) with Motor Impulsiveness were analyzed in a sample of 105 males (mean age 26.71 + 9.68 SEM). Motor Impulsiveness was assessed by Barratt Impulsivity Scale (BIS-10). Sexual hormones including FT, SHBG, luteinizing hormone (LH), follicle- stimulating hormone (FSH), total testosterone (TT) and bio available testosterone (BT) were determined. Hormones were obtained by chromatography and androgen receptor CAG repeat length genotypes by polymerase chain reaction (PCR) techniques. Three groups of subjects were formed according to CGA repeats lengths (short: <20, medium: >20 and <23; and long: >23). Lineal regression models predicting Motor Impulsiveness (dependent variable) were considered including the hormones, GAG repeats genotype and hormone-GAG repeats interaction. Results showed significant interaction between free testosterone (p < 0.001) and SHBG (p < 0.016) with CAG repeats genotype in determining motor impulsiveness following the hypothesized expected direction