Efectos del FGF-1 en la osteointegración de implantes dentalesEstudio piloto en minipigs

Abstract

Objective. IB Pilot study to evaluate an adult minipig model for intaoral dental implantation, and to determinate the effects of acidic fibroblast growth factor (a-FGF, FGF-1) on implant osseointegration. Design of the study. Forty titanium implants, diameter 4,2 mm, with no surface treatment, are implanted in the mandibles of six adult minipigs. Recombinant human acidic fibroblast growth factor, 40 micrograms for each impplant. One side of the mandible is the experimental side, with addition of FGF, and the contralateral side is the control side. Animals are humanely killed after one or three weeks, and the simples are processed for bone densitometry and histological study, without renoval of the implants. Qualitative and quantitative (histomorphometric) studies are performed, and the percentage os osseointegration is calculated. Results. There is a tendency in both group of animals toward a higher percentage of osseointegration in the side treated with FGF. These results, due to the small simple size, are not statiscally significant. Densitometry does not show differences between both sides. Conclusions. The minipig model is adequate for the study of comercial dental implants. FGF-1 may increase the percentage of osseointegration in early stages (one-three weeks), though more studies are necessary if statiscally significant results are to be found. Densitometry is not useful in this experimental design.