Alteraciones del metabolismo mineral y óseo en los pacientes con infección por el virus de la inmunodeficiencia humana
- Sharona Azriel Mira
- Esteban Jódar Gimeno
- Guillermo Martínez Díaz Guerra
- Federico Hawkins Carranza
ISSN: 1132-8460
Year of publication: 2004
Volume: 13
Issue: 3
Pages: 52-59
Type: Article
More publications in: Revista Española de Enfermedades Metabólicas Oseas
Abstract
Recently, a high incidence of osteopenia and osteoporosis has been observed in individuals infected with human immunodeficiency virus (HIV). HIV-infected patients receiving antiretroviral therapy have a high prevalence of reduced bone mineral density. However, patients not receiving antiretrovirals also have a higher than expected prevalence of osteopenia, which suggests that HIV itself may be a contributing factor, mediated by immune activation and cytokines. The variety and complexity of changes in bone metabolism in patients with HIV infection and the different possible mechanisms triggering bone mineral loss, may contribute to the wide range of mineral loss observed and to the uncertainty of the role of specific antiretroviral medications. An improved understanding of the pathogenesis of these bone disorders should result in better preventive and therapeutic measures.